Nucleotides and Enzymes
نویسندگان
چکیده
منابع مشابه
Distribution of Enzymes Cleaving Pyridine Nucleotides in Animal Tissues
1. The distribution of DPN and DPNH pyrophosphatases and DPNase in centrifugally prepared fractions of organs of several species of animals is reported. 2. A DPNH pyrophosphatase was found in the soluble fraction of pigeon and of rabbit liver. This enzyme did not split DPN but accounted for over 50 per cent of the DPNH pyrophosphatase activity of the whole homogenates. 3. All the organs tested,...
متن کاملA membrane network of receptors and enzymes for adenine nucleotides and nucleosides
Most cells express more than one receptor plus degrading enzymes for adenine nucleotides or nucleosides, and cellular responses to purines are rarely compatible with the actions of single receptors. Therefore, these receptors are viewed as components of a combinatorial receptor web rather than self-dependent entities, but it remained unclear to what extent they can associate with each other to ...
متن کاملCyclic nucleotides and their associated enzymes in 9,10-dimethyl-1,2-benzanthracene-induced mammary tumors of rats.
A comparison is presented of the levels of cyclic adenosine 3 :5 -monophosphate, cyclic guanosine 3 :5 -monophosphate (cyclic GMP), adenylate cyclase, guanylate cyclase, cyclic adenosine 3 :5 -monophosphate phosphodiesterase, and cyclic GMP phosphodiesterase in 9,10dimethyl-1,2-benzanthracene-induced mammary tumors of rats and in mammary glands from virgin and midpregnant rats. Many changes wer...
متن کاملA Cascade of Thermophilic Enzymes As an Approach to the Synthesis of Modified Nucleotides
We propose a new approach for the synthesis of biologically important nucleotides which includes a multi-enzymatic cascade conversion of D-pentoses into purine nucleotides. The approach exploits nucleic acid exchange enzymes from thermophilic microorganisms: ribokinase, phosphoribosylpyrophosphate synthetase, and adenine phosphoribosyltransferase. We cloned the ribokinase gene from Thermus sp. ...
متن کاملPyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei
The human pathogenic parasite Trypanosoma brucei possess both de novo and salvage routes for the biosynthesis of pyrimidine nucleotides. Consequently, they do not require salvageable pyrimidines for growth. Thymidine kinase (TK) catalyzes the formation of dTMP and dUMP and is one of several salvage enzymes that appear redundant to the de novo pathway. Surprisingly, we show through analysis of T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1970
ISSN: 0028-0836,1476-4687
DOI: 10.1038/227095a0